BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//CERN//INDICO//EN
BEGIN:VEVENT
SUMMARY:Keynote 4\, Prof. Yvonne Jones: From structure to mechanism in the
  assembly and modulation of cell surface signalling complexes.
DTSTART;VALUE=DATE-TIME:20191010T070000Z
DTEND;VALUE=DATE-TIME:20191010T074000Z
DTSTAMP;VALUE=DATE-TIME:20260526T203228Z
UID:indico-contribution-760@lindico453.srv.lu.se
DESCRIPTION:Speakers: Yvonne Jones  (Univ. of Oxford\, UK)\nIn my laborato
 ry we combine crystallographic\, biophysical\, electron and light microsco
 py based approaches into integrated structural biology analyses to study t
 he assembly and modulation of cell surface signalling complexes involved i
 n development and tissue homeostasis. We aim to generate mechanistic insig
 hts\, at atomic resolution\, which can be tested by functional studies in 
 vitro and in vivo. I will discuss some of the recent results we have gener
 ated by applying this approach to the signalling mechanism of the semaphor
 in-plexin cell guidance system and to the extracellular modulation of sign
 alling by the morphogen Wnt. Published examples of our work on these two s
 ystems include the following:\n\nD. Rozbesky*\, R.A. Robinson\, V. Jain\, 
 M. Renner\, T. Malinauskas\, K. Harlos\, C. Siebold\, and E.Y. Jones*. (20
 19) Diversity of oligomerization in Drosophila semaphorins suggests a mech
 anism of functional fine-tuning. Nature Commun. 10\, 3691.\n\nY. Kong=\, B
 .J.C. Janssen=\, T. Malinauskas\, V.R. Vangoor\, C.H. Coles\, R. Kaufmann\
 , T. Ni\, R.J.C. Gilbert\, S. Padilla-Parra\, R.J. Pasterkamp* and E.Y. Jo
 nes* (2016) ‘Structural basis for plexin activation and regulation.’ N
 euron 91\, 548-560\n\nS. Kakugawa=\, P.F. Langton=\, M. Zebisch=*\, S. How
 ell\, T.-H. Chang\, Y. Liu\, T. Feizi\, G. Bineva\, N. O'Reilly\, A.P. Sni
 jders\, E.Y. Jones* and J.-P. Vincent*. (2015) ‘Notum deacylates Wnts to
  suppress signalling activity.’ Nature 519\, 187-192\n\nhttps://lindico4
 53.srv.lu.se/event/125/contributions/760/
LOCATION:Kulturen Auditorium
URL:https://lindico453.srv.lu.se/event/125/contributions/760/
END:VEVENT
END:VCALENDAR