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SUMMARY:Keynote 10\, Prof Erik Lindahl: Deciphering Allosteric Modulation 
 in Ligand-Gated Ion Channels with Simulations\, X-ray crystallography\, Cr
 yo-EM and Neutron Scattering
DTSTART;VALUE=DATE-TIME:20191011T091000Z
DTEND;VALUE=DATE-TIME:20191011T095000Z
DTSTAMP;VALUE=DATE-TIME:20260525T083946Z
UID:indico-contribution-774@lindico453.srv.lu.se
DESCRIPTION:Speakers: Erik Lindahl (Stockholm University)\nLigand-gated io
 n channels control the electrical excitation of nerve cells\, in particula
 r in the post-synaptic membrane in response to chemical signals mediated b
 y neurotransmitters. These receptors exhibit an amazing diversity in detai
 led structure and function - some human channels have 15-20 slightly genes
 \, and with five subunits this can theoretically lead to almost a million 
 different oligomers. They are further characterised by adopting both close
 d\, open and desensitised states - and in addition to the neurotransmitter
 s causing normal opening they are subject to secondary control - allosteri
 c modulation - by a number of drugs such as alcohols\, benzodiazepines\, n
 eurosteroids\, and anaesthetics that either potentiate or inhibit the agon
 ist response. I will present our work on understanding the molecular mecha
 nisms of these channels by using a broad range of experimental and theoret
 ical methods\, and illustrate that while each method has many shortcomings
  their combination increasingly enable us to capture different timescales\
 , features\, interactions and not least dynamics of important membrane pro
 teins. For ligand-gated ion channels in particular\, this has enabled us t
 o explain several key mechanisms\, including identifying the separate pote
 ntiating and inhibitory binding sites\, showing how we can reverse the all
 osteric modulation of specific channels\, and propose detailed functional 
 models even from intermediate-resolution structural data.\n\nhttps://lindi
 co453.srv.lu.se/event/125/contributions/774/
LOCATION:Kulturen Auditorium
URL:https://lindico453.srv.lu.se/event/125/contributions/774/
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