Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) transporters regulate calcium signaling by active calcium
ion reuptake to internal stores. Several of the structural transitions associated with transport have been characterized
by X-ray crystallography, but critical intermediates of the inward-outward switching are missing.
We combined time-resolved X-ray solution scattering (TR-XSS)...
Ligand-gated ion channels control the electrical excitation of nerve cells, in particular in the post-synaptic membrane in response to chemical signals mediated by neurotransmitters. These receptors exhibit an amazing diversity in detailed structure and function - some human channels have 15-20 slightly genes, and with five subunits this can theoretically lead to almost a million different...
