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SUMMARY:Contr. talk - Comparative X-ray microtomography and SEM to investi
 gate the encapsulating matrix of freeze-dried probiotics
DTSTART;VALUE=DATE-TIME:20210609T140000Z
DTEND;VALUE=DATE-TIME:20210609T142000Z
DTSTAMP;VALUE=DATE-TIME:20260529T230410Z
UID:indico-contribution-1105@lindico453.srv.lu.se
DESCRIPTION:Speakers: Shuai Bai (Lunds universitet)\nThe health effects of
  probiotics are exerted by live and viable microorganisms delivered to the
 ir site of action in the intestine. Thus\, formulating a probiotic product
  that ensures viable cells with long shelf life is one of the main challen
 ges for the industry. A common way to enhance the shelf life is to freeze 
 dry the probiotics with lyo-protectants\, and a large research effort is d
 irected towards finding the best lyo-protectant formulation and drying pro
 cess. Unfortunately\, there is almost no focus on how the structure of the
  freeze dried material can influence the shelf life. Traditional pharmaceu
 tical formulations often demand elegant porous freeze dried cake without c
 ollapse. This kind\nof freeze dried materials often have thin walls and re
 sult in a poor encapsulation of the cells\, which may be detrimental for t
 he stability. The study to be presented aims at understanding how the form
 ulation and drying process together influence the three-dimensional struct
 ure of the freeze-dried material and the cell encapsulation. X-ray micro t
 omography (μCT) is an excellent tool to study freeze-dried material\, inc
 luding the impact of various freeze-drying protocols\, by generating a thr
 ee-dimensional image\, which can be used for further investigating quantit
 ative 3D-parameters\, e.g. the pore size\, pore connectivity\, wall thickn
 ess and tortuosity at a sub-micrometer resolution.\nHere\, μCT is combine
 d with Scanning Electron Microscopy (SEM) and analysis of the specific sur
 face area to give a broader understanding of the structure development and
  how this is reflected in mass transfer resistance during drying and encap
 sulation of the bacterial cells.\n\nhttps://lindico453.srv.lu.se/event/159
 /contributions/1105/
LOCATION:Online on Zoom
URL:https://lindico453.srv.lu.se/event/159/contributions/1105/
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