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SUMMARY:LINXS Amyloid Workshop - Heart and Mind: linking in vitro science 
 to the clinical context
DTSTART;VALUE=DATE-TIME:20210305T140000Z
DTEND;VALUE=DATE-TIME:20210305T180000Z
DTSTAMP;VALUE=DATE-TIME:20260527T231716Z
UID:indico-event-202@lindico453.srv.lu.se
DESCRIPTION:\n\n \n\nWhat: Online (Zoom platform) LINXS Amyloid Workshop.
  The zoom link will be provided just prior to the event.\nDate: March 5\, 
 2021\nNumber of Participants: up to 50\n\nAREA AND AIMS OF THE WORKSHOP  
 \n\nAmyloidoses are diseases caused by the aggregation of proteins and the
 ir accumulation as amyloid fibrils in cells and tissues. Basic science and
  clinical research have made extraordinary progress in the last two decade
 s\, providing clues on the theory of pathological aggregation of proteins 
 and in discovering new diagnostic tools and therapeutic options. Scientist
 s and doctors are trying hard to develop a common translational approach b
 ut inevitably\, due to the biological complexity of disease we should acce
 pt that for long time and without shortcuts\, the two approaches\, might r
 un in parallel. How important is the recognition of the gap between experi
 mental and clinical medicine? How can clinicians and basic scientists best
  establish an effective alliance based on critical thinking and resist the
  pressure to underestimate the differences between experimental model and 
 disease in patients? We should remember the Descartes remark: ‘. . .when
 ever people notice some similarity between two things\, they are in the ha
 bit of ascribing to the one what they find true of the other\, even when t
 he two are not in that respect similar’\n\nMuch research is focused on u
 nderstanding the basic biology of amyloidosis and how it relates to diseas
 e etiology. Integrative structural biology approaches provide unique inter
 disciplinary tools in tackling this very complex and challenging problem\,
  but many crucial questions remain. The workshop will address the synergie
 s and conflicts of technology (reduction) and biomedical complexity (integ
 ration)\n\nWHO SHOULD PARTICIPATE\n\nThe workshop seeks to engage research
 ers from different scientific areas (from basic scientists to clinical res
 earchers) to discuss existing and novel experimental approaches being used
  to understand amyloid and treat patients. Participants may have specific 
 knowledge in methodologies relating to different topics\, or may have a sp
 ecific biological or medical research question that can be addressed by ne
 w technology to study the disease in models and in patients.\n\nFORMAT\n\n
 This will be a half-day online meeting\, introduced by keynote speakers an
 d containing contributed talks/scientific question/solution descriptions. 
 A discussion will then be opened.\n\nDeadline for registration is March 1
 st\, 2021\n\n\n	\n	Registration: Please specify your science area/methodol
 ogy and the session(s) that are of highest interest for you. Please indica
 te if you are willing to contribute a short talk and provide a short abstr
 act.  \n	\n	\n	We ask the participants to send us questions prior to the 
 meeting that you would wish to have addressed during the discussions.\n	\n
 \n\nSPEAKERS\n\nProf. Fabrizio Tagliavini\, National Institute of Neurolog
 y\, Milano\, Italy\nDr. Miriam Solomon\, Temple University\, Philadelphia 
 USA\nProf. Perry Elliott\, Bart’s Heart Centre\, London UK\nProf. Vittor
 io Bellotti\, Royal Free Hospital London/UCL) UK\n\n\nAGENDA\n\n15:00 -15:
 15 Keynote Professor Vittorio Bellotti: “Solving the structure of natura
 l amyloid fibrils: 60 years of progress” \n15:15 - 15:45 Keynote Profess
 or Perry Elliott: “Unanswered questions in TTR related cardiomyopathy”
 \n15:45 - 16:00 Short talk 1: Alexander Büll: “Universal amyloidogenici
 ty of patient-derived\nimmunoglobulin light chains”\n\n16:00 - 16:05 BRE
 AK\n\n16:05 - 16:35 Keynote Prof. Fabrizio Tagliavini: "The complexity of 
 Alzheimer's disease: learning from nature"\n16:35 - 16:50 Short talk 2: Lu
 dmilla Morozova-Roche: “Role of pro-inflammatory S100A9 protein in the\n
 amyloid-neuroinflammatory cascades in neurodegeneration diseases – linki
 ng in vitro and ex vivo studies”\n16:50 - 17:05 Short talk 3: Virginija 
 Danylaite Karrenbauer: “Altered numbers and volumes of secondary lysoso
 mes in circulating monocytes in patients with CSF1R-related leukoencephalo
 pathy”\n\n17:05 - 17:15 BREAK\n\n17:15 - 17:30 Short talk 4: Louise Serp
 ell: “Creating a synthetic paired helical filament”\n17:30 - 18:00 Key
 note Dr. Miriam Solomon: “Making medical knowledge or Medical philosophy
 : Challenging issues in amyloid diseases”\n\n18:00 - 18:05 BREAK\n\n18:0
 5 - 19:00 Discussion: “Synergy and conflict of technology (reduction) an
 d biomedical complexity (integration)”\n\nhttps://lindico453.srv.lu.se/e
 vent/202/
LOCATION:
URL:https://lindico453.srv.lu.se/event/202/
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