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SUMMARY:Neutron research\, Contr. talk 2 - Sucrose versus trehalose as pos
 sible preservatives for proteins
DTSTART;VALUE=DATE-TIME:20210510T122000Z
DTEND;VALUE=DATE-TIME:20210510T124000Z
DTSTAMP;VALUE=DATE-TIME:20260528T085825Z
UID:indico-contribution-1068@lindico453.srv.lu.se
DESCRIPTION:Speakers: Inna Ermilova ()\nSucrose and trehalose are well-kno
 wn industrial preservatives for various purposes: they are widely used in 
 cosmetics\, food conservation and pharmaceutical industry [1\,2]. For inst
 ance\, sucrose is a stabilizing compound of covid-19 vaccine produced by P
 fizer [3]. In this work with the help of atomistic molecular dynamics simu
 lations sucrose and trehalose were considered as agents for preservation o
 f two model-proteins (myoglobin and Aβ(1-42) peptide) at three different 
 water contents. Results of calculations of self-intermediate scattering fu
 nctions demonstrated that systems containing sugars with the smaller amoun
 t of water needed more than 100 ns\, while similar systems without sugars 
 could be relaxed in at around 60-80 ns. Trehalose was the best stabilizing
  agent in all studied cases which could be a consequence of a slower dynam
 ics of this sugar.\n\n[1] Olsson\, Christoffer\, Samuel Genheden\, Victori
 a García Sakai\, and Jan Swenson. "Mechanism of trehalose-induced protei
 n stabilization from neutron scattering and modeling." The Journal of Phys
 ical Chemistry B 123\, no. 17 (2019): 3679-3687.\n[2] Starciuc\, Tatiana\,
  Benjamin Malfait\, Florence Danede\, Laurent Paccou\, Yannick Guinet\, Na
 talia T. Correia\, and Alain Hedoux. "Trehalose or Sucrose: Which of the T
 wo Should be Used for Stabilizing Proteins in the Solid State? A Dilemma I
 nvestigated by In Situ Micro-Raman and Dielectric Relaxation Spectroscopie
 s During and After Freeze-Drying." Journal of pharmaceutical sciences 109\
 , no. 1 (2020): 496-504.\n[3] Vogel\, Annette B.\, Isis Kanevsky\, Ye Che\
 , Kena A. Swanson\, Alexander Muik\, Mathias Vormehr\, Lena M. Kranz et al
 . "BNT162b vaccines protect rhesus macaques from SARS-CoV-2." Nature (2021
 ): 1-7.\n\nhttps://lindico453.srv.lu.se/event/214/contributions/1068/
LOCATION:
URL:https://lindico453.srv.lu.se/event/214/contributions/1068/
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