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SUMMARY:Keynote talk - Recombinant membrane protein production in microbia
 l hosts
DTSTART;VALUE=DATE-TIME:20210525T103500Z
DTEND;VALUE=DATE-TIME:20210525T111500Z
DTSTAMP;VALUE=DATE-TIME:20260722T133153Z
UID:indico-contribution-1128@lindico453.srv.lu.se
DESCRIPTION:Speakers: Roslyn Bill (Aston University\, UK)\nDespite many hi
 gh-profile successes\, recombinant membrane protein production remains a t
 echnical challenge\; it is still the case that many fewer membrane protein
  structures have\nbeen published than those of soluble proteins. However\,
  progress is being made because empirical methods have been developed to p
 roduce the required quantity and quality of\nthese challenging targets. Mi
 crobial expression systems are a key source of recombinant prokaryotic and
  eukaryotic membrane proteins for structural studies. A combination of rat
 ional construct design and host cell choice can dramatically improve membr
 ane protein yields suitable for structural and functional characterization
 . In addition to traditional detergents\, polymer-based systems are availa
 ble for solubilization and biophysical characterization of these proteins\
 , with polymers providing opportunities to investigate protein-lipid inter
 actions.\n\nhttps://lindico453.srv.lu.se/event/219/contributions/1128/
LOCATION:
URL:https://lindico453.srv.lu.se/event/219/contributions/1128/
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