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SUMMARY:Keynote talk - Preparation of lipid flippases for cryo-EM studies
DTSTART;VALUE=DATE-TIME:20210525T133000Z
DTEND;VALUE=DATE-TIME:20210525T141000Z
DTSTAMP;VALUE=DATE-TIME:20260722T001303Z
UID:indico-contribution-1134@lindico453.srv.lu.se
DESCRIPTION:Speakers: Joseph Lyons (Aarhus University\, Denmark)\nP4-ATPas
 es are lipid flippases that drive the ATP-dependent inward translocation (
 flipping) of lipids within the membrane. They are members of the P-type AT
 Pase superfamily and largely function as binary complexes with an auxiliar
 y protein from the CDC50 family. Select lipid flippases are auto-regulated
  by conserved motifs in their termini and require activation by an externa
 l stimulus\, i.e.\, binding of an activating lipid or regulatory protein\,
  and/or specific phosphorylation of the termini.  To elucidate the auto-re
 gulation and transport mechanisms\, we determined the structures of yeast 
 and mammalian lipid flippases by cryo-electron microscopy. \n\nIn this tal
 k\, I will give an overview of the tour de force we embarked on\, from exp
 ression through purification to cryo-EM imaging of these lipid flippases.\
 n\nhttps://lindico453.srv.lu.se/event/219/contributions/1134/
LOCATION:
URL:https://lindico453.srv.lu.se/event/219/contributions/1134/
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