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SUMMARY:Keynote talk - Intestinal peptide and drug uptake – a structure 
 perspective
DTSTART;VALUE=DATE-TIME:20211207T131000Z
DTEND;VALUE=DATE-TIME:20211207T135000Z
DTSTAMP;VALUE=DATE-TIME:20260530T150501Z
UID:indico-contribution-1345@lindico453.srv.lu.se
DESCRIPTION:Speakers: Christian Löw ()\nNutrient uptake across the lipid 
 bilayer is essential for life. Membrane transporters with specialized func
 tions have evolved to maintain the nutrient homeostasis of cells. Many of 
 those are energized by an electrochemical proton gradient. Prominent membe
 rs of such ’secondary active transport system’ are the oligopeptide tr
 ansporters PepT1 and PepT2. Both belong to the Solute Carrier Family 15 (S
 LC15)\, which is highly conserved among all phyla of life. They are known 
 to play key roles in human diseases and impact the pharmacokinetic profile
 s of orally administered drug molecules. I will highlight the approaches t
 hat allowed us to structurally characterize this transporter family. We st
 udied transporter homologs (from bacteria to humans) by structural (X-ray 
 crystallography\, SAXS\, and cryo-EM)\, biochemical and biophysical approa
 ches\, and determined the molecular basis for ligand recognition. The tran
 sporter has been captured in different conformations allowing us to obtain
  a molecular picture of the transport cycle.\n\nhttps://lindico453.srv.lu.
 se/event/250/contributions/1345/
LOCATION:
URL:https://lindico453.srv.lu.se/event/250/contributions/1345/
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