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SUMMARY:The potential for serial crystallography in drug discovery
DTSTART;VALUE=DATE-TIME:20250922T114000Z
DTEND;VALUE=DATE-TIME:20250922T121000Z
DTSTAMP;VALUE=DATE-TIME:20260525T195547Z
UID:indico-contribution-1825@lindico453.srv.lu.se
DESCRIPTION:Speakers: Helena Käck ()\nAndreas Dunge (1\,2)\, Gabrielle We
 hlander (2)\, Gisela Brändén(2) and Helena Käck(1)\n1 Protein Sciences\
 , Structure and Biophysics\, Discovery Sciences\, BioPharmaceuticals R&D\,
  AstraZeneca\, Gothenburg\, Sweden\; 2 Department of Chemistry and Molecul
 ar Biology\, University of Gothenburg\, Box 462\, SE-405 30 Gothenburg\, S
 weden. \n\nStructure-based drug design has played a pivotal role in pharma
 ceutical discovery for over thirty years\, leading to the development of n
 umerous approved therapeutics. Protein crystallography\, relying on data c
 ollection from large single crystals held at cryo temperature\, provides a
  highly optimised and effective workflow for generating structures of comp
 lexes between compounds and their target protein. Still\, this method requ
 ires manual manipulation of thousands of crystals per year for a company s
 uch as AstraZeneca. \nSerial crystallography presents an attractive altern
 ative\, offering potential improvements in throughput and automation by ci
 rcumventing labor-intensive crystal harvesting and facilitating streamline
 d sample preparation. Additionally\, the feasibility of room-temperature d
 ata collection can reduce the risk of structural artefacts introduced by c
 ryo-cooling. Nonetheless\, the adoption of serial crystallography in early
  drug discovery remains challenging due to constraints in speed\, protein 
 and compound availability\, and workflow optimization.\nIn this study\, we
  demonstrate the development and implementation of an optimized serial cry
 stallography workflow tailored for drug discovery applications. Our approa
 ch enables the high-throughput screening of 384 fragments\, addressing som
 e key limitations while paving the way for broader application of serial c
 rystallography in pharmaceutical research.\n\nhttps://lindico453.srv.lu.se
 /event/583/contributions/1825/
LOCATION:LINXS at The Loop
URL:https://lindico453.srv.lu.se/event/583/contributions/1825/
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