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SUMMARY:Time-resolved crystallography of light-driven ion transporters at 
 synchrotrons and free electron lasers
DTSTART;VALUE=DATE-TIME:20250922T132500Z
DTEND;VALUE=DATE-TIME:20250922T135500Z
DTSTAMP;VALUE=DATE-TIME:20260525T195543Z
UID:indico-contribution-1830@lindico453.srv.lu.se
DESCRIPTION:Speakers: Kirill Kovalev (EMBL-Hamburg)\nMicrobial rhodopsins 
 constitute a large superfamily of light-sensitive membrane proteins\, whic
 h are vital for numerous microorganisms on Earth\, and for 20 years also b
 eing most-actively used in neuroscience and medicine in the biotechnology 
 named optogenetics. The major role for optogenetics is played by ion-trans
 porting rhodopsins. Understanding of their molecular mechanisms of functio
 ning can not only contribute to the fundamental biological knowledge of th
 eir roles in native host\, but can enable their optimization towards routi
 ne use in medical application\, such as restoration of eye vision and hear
 ing. I will report on our recent advances in investigations of light-drive
 n ion pumps\, with particular focus on applying time-resolved serial cryst
 allography at X-ray free electron lasers and synchrotrons to obtain molecu
 lar movies of the proteins in action. These include tracking of ultrafast 
 changes and slower but more prominent rearrangements in a new type of sodi
 um transporters\, as well as in inward proton pumps. I will also discuss t
 he optimization of sample delivery for more efficient time-resolved crysta
 llography experiments and its implication for other systems\, such as near
 -infrared-absorbing microbial rhodopsins.\n\nhttps://lindico453.srv.lu.se/
 event/583/contributions/1830/
LOCATION:LINXS at The Loop
URL:https://lindico453.srv.lu.se/event/583/contributions/1830/
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