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SUMMARY:Scientific opportunities for Serial Crystallography at ALBA synchr
 otron
DTSTART;VALUE=DATE-TIME:20250922T162000Z
DTEND;VALUE=DATE-TIME:20250922T163000Z
DTSTAMP;VALUE=DATE-TIME:20260527T002144Z
UID:indico-contribution-1843@lindico453.srv.lu.se
DESCRIPTION:Speakers: Isidro Crespo (ALBA-CELLS)\, Xavi Carpena i Vilella 
 (ALBA-CELLS)\nThe ALBA Synchrotron\, the 3 GeV light source in Southern Eu
 rope\, is preparing for its upgrade to a 4th generation storage ring (ALBA
  II) together with the construction of 3 beamlines and major upgrades on t
 he existing ones\, early next decade. Within this framework\, serial and t
 ime-resolved macromolecular crystallography (SSX and TR-MX) are identified
  as strategic growth areas.\nBL13-XALOC\, in operation since 2012 [1]\, ha
 s been the workhorse MX beamline at ALBA\, delivering photon fluxes up to 
 2.5 × 10¹² ph/s with beam sizes from 50 × 7 μm² to 300 × 100 μm² 
 over 5.2–22 keV. The beamline has undergone an upgrade process including
  a Pilatus-3X 6M (100Hz) detector and a new automated sample changer. Besi
 des\, the beamline is equipped with a high viscosity extrusion injector fo
 r SSX experiments. The transition from single crystal oscillation MX to SS
 X is highly simplified thanks a three-axis motorized stage and sample extr
 usion is facilitated thanks to a PID pressure control system. Proof-of-con
 cept SSX experiments with test proteins have demonstrated compatibility wi
 th room-temperature data collection and negligible radiation damage [2]. P
 ump–probe TR-MX experiments using visible-light activation have also bee
 n successfully performed\, establishing a baseline for further development
 s [3].\nA second MX beamline\, BL06-XAIRA\, started regular user operation
  in June 2025\, offering a highly stable microfocus beam of 3 × 1 μm² a
 nd photon energy range of <4.0–14 keV. Equipped with a <60nm runout diff
 ractometer\, an EIGER2 XE 9M and a dual Channel-Cut/multilayer monochromat
 or [4]\, it enables high-flux\, high-stability microcrystallography. This 
 equipment\, combined with the implementation in the following months of a 
 fast (up to 750 mm/s) SSX stage\, designed for chips up to 60x40 mm will e
 nable fixed-target SSX experiments at higher time resolution. Background r
 eduction and long wavelength experiments are possible due to the recircula
 ted He environment enclosing the entire end station.\nThe ALBA II upgrade 
 plan foresees substantial investment in SSX/TR-MX capabilities for both be
 amlines. For XALOC\, this includes hybrid tape-drive systems for tunable s
 oaking times\, and microfluidic injectors. XAIRA will focus on microfluidi
 c chips\, acoustic droplet ejection\, and conveyor-belt systems for contin
 uous fresh sample delivery. A pump-probe set up will be developed for both
  beamlines to allow for μs–ms TR-MX\, including choppers\, tunable lase
 rs\, and synchronization systems.\n[1] Juanhuix\, J.\, Gil-Ortiz\, F.\, Cu
 ní\, G.\, Colldelram\, C.\, Nicolas\, J.\, Lidon\, J.\, Boter\, E.\, Ruge
 t\, C.\, Ferrer S. & Benach\, J. (2014) Synchrotron Radiat. 21\, 679-689.\
 n[2] Martin-Garcia J.M.\, Botha S.\, Hu H.\, Jernigan R.\, Castellví A.\,
  Lisova S.\, Gil-Ortiz F.\, Calisto B.\, Crespo I.\, Roy-Chowdhury S.\, Gr
 ieco A.\, Ketawala G.\, Weierstall U.\, Spence J.\, Fromme P.\, Zatsepin N
 .\, Boer D.R. & Carpena X. (2022) J. Synchrotron Radiat. 29(3): 896-\n[3] 
 Kovalev K\, et al\, Nat Commun. 2020 May 1\;11(1):2137.\n[4] N. González 
 et al.\, Proc. 12th Int. Conf. Mech. Eng. Design Synchrotron Radiat. Equip
 . Instrum. (MEDSI'23)\, Beijing\, China\, Nov. 2023\, pp.~5-9. doi:10.1842
 9/JACoW-MEDSI2023-TUOAM04\n\n\nAuthors:\nXAVI CARPENA I VILELLA\, ISIDRO C
 RESPO\nCo-authors:\nDAMIÀ GARRIGA\, FERNANDO GIL-ORTIZ\, NAHIKARI GONZÁL
 EZ\, ALEIX TARRÉS\, ALBERT MIRET\, BERNAT MOLAS\, RICARDO VALCÁRCEL\, AL
 EJANDRO ENRIQUE\, CARLES COLLDELRAM\, IGORS ŠICS\, JOSÉ MARÍA ÁLVAREZ\
 , MARCOS QUISPE\, JULIÁN ALBERTO GARCÍA\, ROELAND BOER\, JUDITH JUANHUIX
 \n\nhttps://lindico453.srv.lu.se/event/583/contributions/1843/
LOCATION:LINXS at The Loop
URL:https://lindico453.srv.lu.se/event/583/contributions/1843/
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