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SUMMARY:Modeling X-ray-Induced Heating at 4th-Generation MX Beamlines
DTSTART;VALUE=DATE-TIME:20250923T091500Z
DTEND;VALUE=DATE-TIME:20250923T094500Z
DTSTAMP;VALUE=DATE-TIME:20260526T135938Z
UID:indico-contribution-1849@lindico453.srv.lu.se
DESCRIPTION:Speakers: Michal Kepa (Paul Scherrer Institute)\nThe transitio
 n from 3rd to 4th generation synchrotrons—featuring diffraction-limited 
 storage rings—has significantly expanded future possibilities for macrom
 olecular crystallography (MX). These upgrades\, characterized by reduced s
 ource divergence and increased electron bucket capacity\, have boosted bri
 lliance by up to two orders of magnitude. As a result\, next-generation MX
  beamlines\, such as ID29 (ESRF-EBS)\, BioCARS (APS-U)\, and MicroMAX (MAX
  IV)\, now deliver fluxes approaching 10^15 ph/s. These extremely high flu
 x (EHF) beamlines are increasingly optimized for time-resolved MX\, aiming
  for microsecond-scale resolution.\n\nOperating in previously unexplored d
 ose regimes (>50 GGy/s) raises new challenges. In my presentation\, I woul
 d like to share our study that focuses on beam-induced heating in microcry
 stals (<25 µm) exposed to EHF conditions. Thermal modeling indicates that
  such dose rates may cause significant temperature rises\, potentially imp
 acting data quality. Mitigation strategies include using top-hat beam prof
 iles and increasing both beam and crystal sizes to distribute dose more ev
 enly. The proposed model serves as a tool to support experimental design a
 nd optimize conditions for high-flux time-resolved MX. This of critical im
 portance for future multidimensional X-ray protein crystallography\, espec
 ially in enzymology\, where temperature is a key experimental variable. As
  such they will require precise temperature measurements\, as even a small
  change in temperature can affect the catalytic activity of an enzyme.\n\n
 \nAuthors: Michal Kepa\, John Beale\, Martin Appleby\n\nhttps://lindico453
 .srv.lu.se/event/583/contributions/1849/
LOCATION:LINXS at The Loop
URL:https://lindico453.srv.lu.se/event/583/contributions/1849/
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